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Evaluation of Antioxidant, Antimicrobial and Cytotoxicity of Alcea kurdica Alef
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Material Type |
Article
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Author(s) |
Qader, Suhailah W. (Author)
Awad, Hassan M. (Author)
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Source Journal Info. |
Title:
Jordan journal of biological sciences
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Volume/ Issue No.: 2014/DEC V.7 N.4
Call No.:570.5 J J B Location: Periodicals & References Hall - 2nd floor
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Physical Description |
p 205-209
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Subject Area/ Descriptors |
Life sciences (Biology)
(1295)
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Abstract |
The purpose of this study is to evaluate the aqueous extract of Alcea kurdica Alef for antioxidant and antimicrobial activity
as well as potential toxicity. Antioxidant activities were evaluated using 1,1-diphenyl-2- picrylhydrazyl (DPPH) free
radical scavenging and Ferric Reducing Antioxidant Power (FRAP) reducing capacity assays as well as total phenolic
compounds (TPC). Antimicrobial activity was assessed against some Gram-positive and Gram-negative bacteria, yeasts
and filamentous fungi using the agar dilution method. The plant extract was also assessed for in-vitro toxicity using the
Promega Cell Titer 96 AQueous Non-Radioactive Cell Proliferation (MTS) assay. The aqueous extract of A. kurdica
demonstrated potent free radical scavenging activity of 64% ± 1.64% and ferric reduction capacity of 2955.0 ± 0.04
mmol/g, as well as having 88.0 ± 0.002 mg gallic acid equivalents /gram plant extract. The aqueous extract of A. kurdica
had modest antimicrobial activity against most tested microorganisms. Moreover, the plant extract did not have any toxic
effects on human lung fibroblasts. Based on these findings, we conclude that A. kurdica may be utilized to prevent the
growth of some microorganisms. The plant constituents behind these effects are the antioxidants and phenols. Further
studies are needed to evaluate the therapeutic utility of A. kurdica extracts as antimicrobial agents....
Full Abstract
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Journal:
Jordan journal of biological sciences
(44)
Issu: 2014/DEC V.7 N.4
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