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Online Catalog - Item information
Philadelphia   University
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Date:12/05/24

 

Publication type: Article
Title:

Pneumococcus with the “6E” cps Locus Produces Serotype 6B Capsular Polysaccharide

Author(s): Burton,Robert L. (Author) Geno,K. Aaron (Author)
Source Journal Info. Title:Journal of Clinical Microbiology
Issue Number:2016/APR V.54 N.4
Call No.:616.0105 JCM
Location: References & Periodical Hall - 2nd floor
Physical Description: p 967-971
Subject Area: Medical sciences
Subject Terms:  Pharmacy 
Accession Number 154855
Abstract
Genetic studies of serogroup 6 isolates of Streptococcus pneumoniae identified putative serotype 6E. Although its capsular polysaccharide structure has not been elucidated, putative serotype 6E is described in an increasing number of studies as a potentially new serotype. We show here that SPEC6B, which is widely used as a target strain for serotype 6B opsonophagocytosis assays, has the genetic features of the putative serotype 6E but produces capsular polysaccharide identical to 6B capsular polysaccharide as determined by one-dimensional (1D) and 2D nuclear magnetic resonance (NMR). Thus, putative serotype 6E is a mere genetic variant of serotype 6B. Also, SPEC6B is appropriate as a target strain for serotype 6B opsonophagocytosis assays. This example illustrates the difficulties of assigning new bacterial serotypes based on genetic findings alone. ...

Abstract URL:http://jcm.asm.org/content/54/4/967.abstract
Online Catalog - Item information
Philadelphia   University
Library & Information Resources 

Technical   Services   Department
Online Catalog - Item Information
Date:12/05/24

 

Publication type: Article
Title:

Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B

Author(s): Geno,K. Aaron (Author) Saad,Jamil S. (Author)
Source Journal Info. Title:Journal of Clinical Microbiology
Issue Number:2017/MAY V.55 N.5
Call No.:616.0105 JCM
Location: References & Periodical Hall - 2nd floor
Physical Description: p 1416-1425
Subject Area: Medical sciences
Subject Terms:  Pharmacy 
Accession Number 161269
Abstract
Pneumococcus (Streptococcus pneumoniae) remains a significant cause of morbidity and mortality, especially among those at the extremes of age. Its capsular polysaccharide is essential for systemic virulence. Over 90 serologically distinct pneumococcal capsular polysaccharides (serotypes) are recognized, but they are unequal in prevalence. ...

Abstract URL:http://jcm.asm.org/content/55/5/1416.abstract
Philadelphia   University
Library & Information Resources 

Technical   Services   Department
Online Catalog - Item Information
Date:12/05/24

 

Publication type: Article
Title:

WciG O-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42

Author(s): Aaron Geno,K (Author) Allen Bush,C (Author) Wang,Mengnan (Author)
Source Journal Info. Title:Journal of clinical microbiology
Issue Number:2017/SEP V.55 N.9
Call No.:616.0105 JCM
Location: References & Periodical Hall - 2nd floor
Physical Description: p 2775-2784
Subject Area: Medical sciences
Subject Terms:  Pharmacy 
Accession Number 164279
Abstract
Streptococcus pneumoniae expresses capsular polysaccharides (CPSs) to protect itself from opsonophagocytic killing. The genes responsible for capsules synthesized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule types ...

Abstract URL:http://jcm.asm.org/content/55/9/2775.abstract

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