| نوع المادة:
مقال
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| العنوان |
WQ-3810 exerts high inhibitory effect on quinolone-resistant DNA gyrase of Salmonella Typhimurium
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| المؤلف/ المؤلفين |
Koide,Kentaro
(Author)
Kongsoi,Siriporn
(Author)
Nakajima,Chie
(Author)
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| بيانات المجلة المصدر |
العنوان: Bioscience, biotechnology, and biochemistry
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العدد: 2019/DEC V.83 N.12
رقم الإستدعاء: 547.19205 BBB
الموقع: قاعة المراجع والدوريات - الطابق الثاني
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| الوصف المادي |
p 2249-2256
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| رأس الموضوع |
الكيمياء
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| الواصفات |
Biochemistry
Chemistry, Organic
Biotechnology
Biological Science Disciplines
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| رقم التزويد |
179703
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المستخلص
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The inhibitory effect of WQ-3810 on DNA gyrase was assayed to evaluate the potential of WQ-3810 as a candidate drug for the treatment of quinolone resistant Salmonella Typhymurium infection. The inhibitory effect of WQ-3810, ciprofloxacin and nalidixic acid was compared by accessing the drug concentration that halves the enzyme activity (IC50) of purified S. Typhimurium wildtype and mutant DNA gyrase with amino acid substitution at position 83 or/and 87 in subunit A (GyrA) causing quinolone resistance. As a result, WQ-3810 reduced the enzyme activity of both wildtype and mutant DNA gyrase at a lower concentration than ciprofloxacin and nalidixic acid. Remarkably, WQ-3810 showed a higher inhibitory effect on DNA gyrase with amino acid substitutions at position 87 than with that at position 83 in GyrA. This study revealed that WQ-3810 could be an effective therapeutic agent, especially against quinolone resistant Salmonella enterica having amino acid
substitution at position 87. ...
رابط المستخلص: https://www.tandfonline.com/doi/abs/10.1080/09168451.2019.1650634
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