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Publication type: Article
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| Title: |
Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs
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| Author(s): |
van Speybroeck,Michiel
(Author)
Mellaerts,Randy
(Author)
Do Thi,Thao
(Author)
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| Source Journal Info. |
Title:Journal of Pharmaceutical Sciences
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Issue Number:2011/NOV V.100 N.11
Call No.:615.05 JPS
Location: References & Periodical Hall - 2nd floor
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| Physical Description: |
p 4864–4876
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| Subject Area: |
Medical sciences
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| Subject Terms: |
Pharmacy
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| Accession Number |
145816
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Abstract
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This study aimed to assess the pharmaceutical performance of formulations consisting of either indomethacin or glibenclamide and the ordered mesoporous silica material SBA-15. Both compounds were loaded on SBA-15 via solvent impregnation. Adsorption in the SBA-15 mesopores was confirmed using nitrogen physisorption. ...
Abstract URL:http://onlinelibrary.wiley.com/doi/10.1002/jps.22703/abstract
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