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Publication type: Article
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Title: |
Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1
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Author(s): |
Verhoff,Moritz
(Author)
Seitz,Stefanie
(Author)
Paul,Michael
(Author)
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Source Journal Info. |
Title:Journal of Natural Products
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Issue Number:2014/JUN V.77 N.6
Call No.:547.005 JNP Location: References & Periodical Hall - 2nd floor
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Physical Description: |
p 1445–1451
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Subject Area: |
Chemistry
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Subject Terms: |
Natural products
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Accession Number |
137714
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Abstract
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The microsomal prostaglandin E2 synthase (mPGES)-1 is the terminal enzyme in the biosynthesis of prostaglandin (PG)E2 from cyclooxygenase (COX)-derived PGH2. We previously found that mPGES-1 is inhibited by boswellic acids (IC50 = 3–30 µM), which are bioactive triterpene acids present in the anti-inflammatory remedy frankincense. Here we show that besides boswellic acids ...
Abstract URL:http://pubs.acs.org/doi/abs/10.1021/np500198g
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