Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1
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نوع المصدر |
مقال
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بيانات التأليف |
Verhoff, Moritz (Author)
Seitz, Stefanie (Author)
Paul, Michael (Author)
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بيانات الدورية المصدر |
العنوان:
Journal of Natural Products
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رقم المجلد/ العدد: 2014/JUN V.77 N.6
رقم الإستدعاء: 547.005 JNP الموقع: Periodicals & References Hall - 2nd floor
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الوصف المادي |
p 1445–1451
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رأس الموضوع/ الواصفات |
Chemistry
(2846)
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المستخلص |
The microsomal prostaglandin E2 synthase (mPGES)-1 is the terminal enzyme in the biosynthesis of prostaglandin (PG)E2 from cyclooxygenase (COX)-derived PGH2. We previously found that mPGES-1 is inhibited by boswellic acids (IC50 = 3–30 µM), which are bioactive triterpene acids present in the anti-inflammatory remedy frankincense. Here we show that besides boswellic acids...
المستخلص الكامل
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| المزيد من المقالات من
الدورية:
Journal of Natural Products
(1665)
العدد: 2014/JUN V.77 N.6
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