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Publication type: Article
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| Title: |
Tannins and Tannin-Related Derivatives Enhance the (Pseudo-)Halogenating Activity of Lactoperoxidase
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| Author(s): |
Gau,Jana
(Author)
Prévost,Martine
(Author)
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| Source Journal Info. |
Title:Journal of Natural Products
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Issue Number:2017/MAY V.80 N.5
Call No.:547.005 JNP
Location: References & Periodical Hall - 2nd floor
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| Physical Description: |
p 1328–1338
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| Subject Area: |
Chemistry
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| Subject Terms: |
Natural products
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| Accession Number |
161122
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Abstract
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Several hydrolyzable tannins, proanthocyanidins, tannin derivatives, and a tannin-rich plant extract of tormentil rhizome were tested for their potential to regenerate the (pseudo-)halogenating activity, i.e., the oxidation of SCN– to hypothiocyanite –OSCN, of lactoperoxidase (LPO) after hydrogen peroxide-mediated enzyme inactivation. Measurements were performed using 5-thio-2-nitrobenzoic acid in the presence of tannins and related substances in order to determine kinetic parameters and to trace the LPO-mediated –OSCN formation. The results were combined with docking studies and molecular orbital analysis. ...
Abstract URL:http://pubs.acs.org/doi/10.1021/acs.jnatprod.6b00915
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