Deep Sequencing of HIV-1 RNA and DNA in Newly Diagnosed Patients with Baseline Drug Resistance Showed No Indications for Hidden Resistance and Is Biased by Strong Interference of Hypermutation
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Material Type |
Article
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Author(s) |
Dauwe, Kenny (Author)
Staelens, Delfien (Author)
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Source Journal Info. |
Title:
Journal of Clinical Microbiology
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Volume/ Issue No.: 2016/JUN V.54 N.6
Call No.:616.0105 JCM Location: Periodicals & References Hall - 2nd floor
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Physical Description |
p 1605-1615
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Subject Area/ Descriptors |
Medical sciences
(12461)
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Abstract |
Deep sequencing of plasma RNA or proviral DNA may be an interesting alternative to population sequencing for the detection of baseline transmitted HIV-1 drug resistance. Using a Roche 454 GS Junior HIV-1 prototype kit, we performed deep sequencing of the HIV-1 protease and reverse transcriptase genes on paired plasma and buffy coat samples from newly diagnosed HIV-1-positive individuals. Selection was based on the outcome of population...
Full Abstract
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Journal:
Journal of Clinical Microbiology
(3691)
Issu: 2016/JUN V.54 N.6
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