Implementation of Next-Generation Sequencing for Hepatitis B Virus Resistance Testing and Genotyping in a Clinical Microbiology Laboratory
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Material Type |
Article
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Author(s) |
Lowe, Christopher F. (Author)
Merrick, Linda (Author)
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Source Journal Info. |
Title:
Journal of Clinical Microbiology
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Volume/ Issue No.: 2016/JAN V.54 N.1
Call No.:616.0105 JCM Location: Periodicals & References Hall - 2nd floor
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Physical Description |
p 127-133
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Subject Area/ Descriptors |
Medical sciences
(12461)
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Abstract |
Sanger sequencing or DNA hybridization have been the primary modalities for hepatitis B (HBV) resistance testing and genotyping; however, there are limitations, such as low sensitivity and the inability to detect novel mutations. Next-generation sequencing (NGS) for HBV can overcome these limitations, but there is limited guidance for clinical microbiology laboratories to validate this novel technology. In this study, we describe...
Full Abstract
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Journal:
Journal of Clinical Microbiology
(3691)
Issu: 2016/JAN V.54 N.1
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