Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs
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Material Type |
Article
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Author(s) |
van Speybroeck, Michiel (Author)
Mellaerts, Randy (Author)
Do Thi, Thao (Author)
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Source Journal Info. |
Title:
Journal of Pharmaceutical Sciences
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Volume/ Issue No.: 2011/NOV V.100 N.11
Call No.:615.05 JPS Location: Periodicals & References Hall - 2nd floor
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Physical Description |
p 4864–4876
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Subject Area/ Descriptors |
Medical sciences
(12461)
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Abstract |
This study aimed to assess the pharmaceutical performance of formulations consisting of either indomethacin or glibenclamide and the ordered mesoporous silica material SBA-15. Both compounds were loaded on SBA-15 via solvent impregnation. Adsorption in the SBA-15 mesopores was confirmed using nitrogen physisorption....
Full Abstract
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Journal:
Journal of Pharmaceutical Sciences
(785)
Issu: 2011/NOV V.100 N.11
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